The writer and creator said that he could understand fan disappointment, but praised the BBC for its encouragement and support with the supernatural series, which he described as "the little show that could".
"A preposterous idea, an epic and circuitous development process, a modest budget - no, we really shouldn't have lasted," wrote Whithouse, who admitted that he couldn't believe his project had spawned 37 episodes, American and online spinoffs, and three novels.
Whithouse thanked his team of writers and various actors across the five series - who have included Russell Tovey, Lenora Crichlow, Aiden Turner, Michael Socha and Damien Molony.
Speaking about the BBC's support for the series, he praised the broadcaster's "unprecedented level of creative latitude". He also suggested that it was time for the show to move on to "make space for the next Being Human".
Photo gallery - Being Human's next episode 'Sticks and Ropes':