Stephen Colbert and Mumford & Sons will also be on hand for the Secret Policeman's Ball to raise money for Amnesty International.
The first official Secret Policeman's Ball was held at Her Majesty's Theatre in London in 1979 and featured members of Monty Python appearing in skits as well as musical performances from Pete Townshend and 'Glad to Be Gay' singer Tom Robinson.
Comedy icons Rowan Atkinson, Peter Cook and Billy Connolly and musicians Bob Geldof, Sting and Bono appeared in the ensuing series of Secret Policeman's Balls throughout the 1980s.
Amnesty International spokesman Andy Hackman said that the Secret Policeman's Ball will be reinvigorated by its move across the Atlantic.
"For us, it's iconic and a very special thing, and has provided the opportunity to really celebrate the presence of freedom of expression and free speech, and how we can move people and how we can bring people together, and just how powerful that is," Hackman declared.
The last Secret Policeman's Ball gala took place in London in 2008 and featured headliners Graham Norton, Kristen Schaal, Mitchell and Webb and Katy Brand.