Following news of her passing, Oakenfold wrote on Twitter: "RIP Amy Winehouse your smokey jazzy voice will live on."
Asked what he loved about Winehouse, he explained to Digital Spy: "It was all about her voice. For me it was the tone, it was the delivery, it was the edginess - the power of her getting behind the song and making it come alive.
"We've got some really good singers in England who can do that. Obviously, with Adele flying... I certainly thought that Amy Winehouse was one of those special singers. That was a real shame."
Oakenfold agreed that there were parallels between Winehouse's well-documented addiction problems and those of the Happy Mondays, whose breakthrough album Pills 'n' Thrills and Bellyaches he produced with Steve Osborne in 1990.
"Yeah, absolutely," he said. "In the heyday when the Monday were as big as Amy I suppose - when they were playing Wembley Arena and their records were top five - it was chaos.
"It was very unpredictable chaos in some shape and form and everyone saw it as fun. Thank god no-one did cross the line and die, because there was a lot of abuse going on."
On whether the industry can help those affected by drug addiction, the DJ added: "It's down to the individual. The music industry as a whole - we're all grown up, we all know what we should do and what we shouldn't do, but some individuals are just in a situation where they find it difficult.
"I don't think we should glamorise it, I certainly don't. I don't understand it. I think it was a real sorry situation for anyone to die of drugs."
Oakenfold this week releases new 41-track mix Never Mind The B*llocks... Here's Paul Oakenfold via his relaunched Perfecto Fluoro label. He plays the Gatecrasher residency at Ibiza's Privilege on August 10, 17, 24 and 31.